Efficient unified synthesis of diverse bridged polycyclic scaffolds using a complexity-generating ‘stitching’ annulation approach
نویسندگان
چکیده
Regioselective and stereospecific directed C–H arylation of simple amine substrates, cyclisation, delivered 30 diverse, three-dimensional scaffolds.
منابع مشابه
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Controlling the properties of lead molecules is critical in drug discovery, but sourcing large numbers of lead-like compounds for screening collections is a major challenge. A unified synthetic approach is described that enabled the synthesis of 52 diverse lead-like molecular scaffolds from a minimal set of 13 precursors. The divergent approach exploited a suite of robust, functional group-tole...
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2021
ISSN: ['1359-7345', '1364-548X']
DOI: https://doi.org/10.1039/d0cc06975b